Yohimbine Hydrochloride (98.15%) is an indole alkaloid salt commonly utilized in analytical laboratories for chemical characterization, reference standard development, chromatographic validation, and alkaloid research. As the hydrochloride salt of yohimbine, this compound exhibits improved aqueous solubility compared with its free-base form, making it particularly useful in analytical workflows involving solution preparation and instrumental analysis. Its well-characterized molecular structure and established analytical profile have made it a frequently referenced compound in natural product chemistry and alkaloid research. IsoPep Sciences supplies this material exclusively as a laboratory research chemical for analytical and scientific investigation.

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Chemical Profile

Chemical Name: Yohimbine Hydrochloride

IUPAC Name: Methyl (1R,15S,17β)-17-hydroxyyohimban-16-carboxylate hydrochloride

CAS Number: 65-19-0

Molecular Formula: C₂₁H₂₇ClN₂O₃

Molecular Weight: 390.90 g/mol

Chemical Class: Indole alkaloid hydrochloride

Synonyms:

• Yohimbine HCl
• Yohimbine Hydrochloride
• α-Yohimbine Hydrochloride
• Corynine Hydrochloride

Appearance: White to off-white crystalline powder

Purity: 98.15% (batch-specific)

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Structural Characteristics

Yohimbine hydrochloride is a pentacyclic indole alkaloid containing a fused-ring yohimban skeleton composed of an indole nucleus, multiple saturated ring systems, an ester functional group, a hydroxyl substituent, and a protonated tertiary amine associated with hydrochloride. The molecule possesses several stereogenic centers that contribute to its well-defined three-dimensional structure.

The hydrochloride salt increases the compound’s water solubility and can influence its chromatographic behavior, crystallization properties, and analytical handling characteristics. The presence of both aromatic and heterocyclic structural elements makes the compound suitable for a variety of spectroscopic and chromatographic analytical applications.

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Analytical Considerations

Typical laboratory characterization may include:

• High-Performance Liquid Chromatography (HPLC)
• Ultra-Performance Liquid Chromatography (UPLC)
• Gas Chromatography–Mass Spectrometry (GC-MS)
• Liquid Chromatography–Mass Spectrometry (LC-MS)
• Proton Nuclear Magnetic Resonance (^1H NMR)
• Carbon-13 Nuclear Magnetic Resonance (^13C NMR)
• Fourier Transform Infrared Spectroscopy (FTIR)
• Melting point analysis

Batch-specific Certificates of Analysis should be referenced when available.

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Handling & Storage

• Store in a tightly sealed container.
• Protect from excessive heat, moisture, and direct sunlight.
• Store in a cool, dry environment.
• Handle using appropriate laboratory PPE.
• Use only in properly equipped laboratory environments.

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Research Use Disclaimer

This product is supplied exclusively for legitimate laboratory research, analytical testing, and scientific investigation. It is not intended for human consumption, veterinary use, therapeutic applications, food use, cosmetic use, or household use. Researchers are responsible for handling this material in accordance with applicable laboratory safety procedures and regulations.